4.2.1. Synthesis, characterization and antibacterial activity of cyclohexyltin N-(salicylidene)valinates


Xiaowen Shi, Guochao Kong, Lin Liu, Hong Gao, Xue Gao, Laijin Tian*

Key Laboratory of Natural Products and Pharmaceutical Intermediates, Qufu Normal University, Qufu 273165, China.

* Corresponding author, e-mail: laijintian@163.com

Received: April 14, 2016; accepted: May 22, 2016

Abstract: Two new cyclohexyltin N-(salicylidene)valinates, [2-HOC6H4CH=NCH(CH(CH3)2)COO]SnCy3 (1) and [2-OC6H4CH=NCH(CH(CH3)2)COO]SnCy2 (2) (Cy = cyclohexyl), have been synthesized and characterized by elemental analysis, IR, and 1H NMR. The crystal structure of 2 has been determined by X-ray single crystal diffraction. In the complexes, the carboxylate is monodentate. Complex 1 is a four-coordinated tin compound, and 2 has a distorted trigonal bipyramidal geometry with the axial locations occupied by one carboxylate oxygen and a phenolic oxygen of the ligand. Bioassay results show that 1 and 2 have good in vitro antibacterial activity against Escherichia coli.

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